1217-Irg1/Itaconate Rewires Macrophage and Tumor Metabolism

This research identifies IRG1-derived itaconate as a critical metabolic regulator that restricts lung cancer progression. By employing spatial metabolomics, the authors discovered that itaconate is naturally depleted within tumor regions, and its absence accelerates malignant growth and metastasis. Mechanistically, itaconate inhibits G6PD activity, which suppresses the pentose phosphate pathway and reduces the production of essential building blocks for cancer cell proliferation. Furthermore, restoring itaconate levels through the derivative Octyl itaconate successfully reprograms pro-tumor macrophages into an anti-tumor state. These findings establish a therapeutic link between metabolic rewiring and immune system activation, suggesting new strategies for treating lung adenocarcinoma. Through multi-omics analysis, the study confirms that targeting the itaconate-G6PD axis can directly stall tumor cell division while enhancing protective immune responses.References:Mansouri S, Hesami G, Ambikan A, et al. IRG1/itaconate rewires macrophage and lung tumor metabolism through G6PD inhibition[J]. Cell Metabolism, 2026.前往小宇宙评论区与主播互动