EPISODE · Jul 2, 2026 · 16 MIN
1217-衣康酸通过抑制G6PD重塑巨噬细胞与肺癌代谢
from 聊聊Sci
这项研究揭示了IRG1及其产物衣康酸（itaconate）在抑制肺癌生长中的关键作用。通过空间代谢组学分析，研究人员发现肺部肿瘤区域普遍缺乏衣康酸，而这种缺失会加速肿瘤的恶化。实验表明，衣康酸衍生物（4-辛酯衣康酸）能够通过非共价结合直接抑制葡萄糖-6-磷酸脱氢酶（G6PD）的活性，从而阻断磷酸戊糖途径（PPP）。这种代谢重塑不仅直接限制了癌细胞的增殖，还能将肿瘤相关巨噬细胞从促癌状态重新编程为抗癌状态。最终，该研究证明了利用IRG1/衣康酸轴或其衍生物是一种极具潜力的肺癌治疗新策略。References:Mansouri S, Hesami G, Ambikan A, et al. IRG1/itaconate rewires macrophage and lung tumor metabolism through G6PD inhibition[J]. Cell Metabolism, 2026.前往小宇宙评论区与主播互动
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1217-衣康酸通过抑制G6PD重塑巨噬细胞与肺癌代谢
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