EPISODE · Jul 2, 2026 · 33 MIN
1218-SPACE-seq：组织原位整合空间转录组与谱系追踪技术
from 聊聊Sci
这项研究介绍了一种名为 SPACE-seq 的创新生物技术，该技术首次将 CRISPR 谱系追踪与空间转录组学深度整合。通过在原生组织中同时记录细胞的演化后代、转录状态及精确位置，研究者能够以前所未有的分辨率解析组织架构的形成。利用这一工具，科学家揭示了肝癌内部克隆细胞的表型多样性，并发现肿瘤与基质之间存在重塑彼此命运的信号交互。此外，该技术还成功构建了大脑发育的三维谱系图谱，发现了海马体子区域形成过程中的对称克隆规律。SPACE-seq 不仅揭示了肝脏发育中肝母细胞扩散的关键窗口，还为理解复杂疾病与发育生物学提供了极具普适性的研究平台。References:Jia Y, Sun D, Weir J A, et al. SPACE-seq integrates spatial transcriptomics and lineage tracing in native tissues[J]. Cell Stem Cell, 2026.前往小宇宙评论区与主播互动
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1218-SPACE-seq：组织原位整合空间转录组与谱系追踪技术
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