EPISODE · Jul 2, 2026 · 18 MIN
1220-基因编辑猪-人多器官原位异种移植研究
from 聊聊Sci
这项研究报道了全球首例在人类受体（脑死亡患者）体内进行的原位全肝及双肾多器官异种移植实验。研究人员采用六项基因编辑的猪作为供体，通过精密的外科手术成功替代了受体的相应器官。监测数据表明，移植物在约五天的观察期内维持了基本的生理功能，未出现超急性排斥反应，且猪源肝脏展现了有效的代谢与分泌能力。通过单细胞测序与代谢组学分析，科研人员识别出S100A12+中性粒细胞是免疫反应的核心参与者，并证实受体系统正向人体代谢谱转变。这一突破性的医学模型不仅验证了多器官异种移植的技术可行性，也为未来临床转化提供了系统的免疫与代谢框架。References:Liao J, An S, Dong J, et al. First human decedent model of orthotopic multi-organ xenotransplantation: Whole liver and bilateral kidneys from a six-gene-edited pig[J]. Med, 2026, 7(6).前往小宇宙评论区与主播互动
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1220-基因编辑猪-人多器官原位异种移植研究
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