1222-单细胞测序揭示免疫检查点抑制剂与放射性肺炎差异特征

这项研究利用单细胞测序技术，深入探讨了肺癌治疗中两种极易混淆的副作用：免疫检查点抑制剂肺炎 (CIP) 和放射性肺炎 (RP) 之间的细胞学差异。研究人员发现，CIP 的肺部炎症主要由源自肺部组织的 ZNF683hi 耗竭性 CD8+ T 细胞驱动，表现出明显的组织驻留特征。相比之下，RP 的发生则与来自外周血液的 GZMKhi 耗竭性 CD8+ T 细胞密切相关，显示出完全不同的分化轨迹。通过识别这些独特的免疫生物标志物，科学家们能够更精准地进行鉴别诊断，从而为临床决策提供依据。这些发现不仅揭示了两种肺炎截然不同的致病机制，还为肺癌患者在出现肺炎后能否安全地再次启动免疫治疗提供了科学指导。该成果最终发表于 2026 年的《Med》杂志，为优化癌症综合治疗的安全性策略做出了贡献。References:Zhou X, Jiang Z, Ren Y, et al. Single-cell profiling unveils an exhaustion trajectory of ZNF683hi tissue-resident alveolar CD8+ T cells in checkpoint inhibitor pneumonitis[J]. Med, 2026.前往小宇宙评论区与主播互动

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1222-单细胞测序揭示免疫检查点抑制剂与放射性肺炎差异特征

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