EPISODE · Jul 3, 2026 · 13 MIN
1223-CAR T细胞治疗复发性胶母细胞瘤的内源免疫演变
from 聊聊Sci
这份文章探讨了在复发性胶质母细胞瘤患者中，通过脑室内注射 CAR T 细胞疗法后的免疫反应机制。研究人员利用单细胞 RNA 测序和光谱流式细胞术等先进技术，详细分析了治疗后患者脑脊液及肿瘤组织内免疫环境的演变。研究重点揭示了宿主自身内源性免疫系统在治疗过程中的关键作用，观察到治疗引发了显著的免疫细胞表型转化。实验数据进一步表明，恶性细胞在压力下会发生间质化转变并建立代谢防御屏障，从而产生治疗耐药性。该研究不仅提供了详尽的分子图谱，还为优化针对脑部恶性肿瘤的细胞免疫疗法提供了理论依据。References:Freeburg N F, Chafamo D, Gopikrishna G K, et al. The critical role of the endogenous immune compartment after CAR T cell therapy in recurrent GBM[J]. Cell, 2026.前往小宇宙评论区与主播互动
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1223-CAR T细胞治疗复发性胶母细胞瘤的内源免疫演变
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