EPISODE · Jul 5, 2026 · 22 MIN
1233-Meg3+造血干细胞谱系命运与免疫衰老机制研究
from 聊聊Sci
这项研究通过单细胞多组学技术，揭示了造血干细胞（HSC）随年龄增长导致免疫衰老的核心机制。研究人员鉴定出一群以Meg3为标志的特定干细胞亚群，它们在衰老过程中显著扩张，并诱发血液系统向髓系和巨噬细胞偏移，同时减少淋巴细胞生成。实验证明，炎症信号激活了H3K23ac这一表观遗传修饰，通过招募TRIM24蛋白增强了转录因子PU.1的活性，从而驱动谱系失衡。最关键的是，阻断这种表观遗传相互作用可以纠正衰老干细胞的造血偏差，并减轻衰老相关的分泌表型。该发现为逆转老年人免疫功能下降及降低慢性炎症相关疾病风险提供了潜在的治疗靶点。References:Wei N, Zhan H, Deng Y, et al. Epigenetic programming by H3K23ac defines lineage fate of Meg3+ haematopoietic stem cells and drives immune ageing[J]. Nature Cell Biology, 2026: 1-20.前往小宇宙评论区与主播互动
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1233-Meg3+造血干细胞谱系命运与免疫衰老机制研究
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