EPISODE · Jul 6, 2026 · 26 MIN
1238-综合压力响应驱动肺癌细胞谱系重塑与进化
from 聊聊Sci
这篇研究探讨了整合应激反应（ISR）在肺腺癌演化中的核心作用。研究通过小鼠模型发现，ISR的激活能够驱动肿瘤细胞向高可塑性及去分化状态转变，从而增强肿瘤的异质性和生存能力。与之相对，抑制该通路会导致肿瘤细胞出现线粒体功能障碍，并将其发育锁定在一种低适应性的萎缩状态。ATF4和MYC被确认为介导这一谱系重编程的关键分子，它们共同维持了恶性细胞在压力环境下的代谢稳态。最终，该研究揭示了ISR是肺癌向晚期进展的重要动力，并为临床提供了潜在的治疗靶点。References:Diao S, Zou J Y, Wang S, et al. Integrated stress response couples mitochondrial fitness with lineage reprogramming to drive cancer evolution[J]. Nature Cell Biology, 2026: 1-16.前往小宇宙评论区与主播互动
Embed this episode
NOW PLAYING
1238-综合压力响应驱动肺癌细胞谱系重塑与进化
0:00
26:09
1×
No transcript for this episode yet
Similar Episodes
No similar episodes found.
Similar Podcasts
Frequently Asked Questions
How long is this episode of 聊聊Sci?
This episode is 26 minutes long.
When was this 聊聊Sci episode published?
This episode was published on July 6, 2026.
Can I download this 聊聊Sci episode?
Yes. Use the download control on the episode player to save the publisher-provided media file.
URL copied to clipboard!