EPISODE · Jul 7, 2026 · 16 MIN
1241-RNA强化染色质凝聚物成核并放大致癌转录
from 聊聊Sci
这项研究揭示了本地转录生成的RNA如何通过增强致癌蛋白ENL突变体在染色质上的凝聚物成核，进而驱动肿瘤发生。研究发现，突变型ENL利用其YEATS结构域中的碱基位点与RNA结合，这种相互作用显著提高了致癌基因所在位点的转录爆发频率和蛋白占有率。通过化学诱导位移系统，科学家证明了阻断RNA结合或抑制转录会阻碍凝聚物重新形成，从而削弱ENL介导的促癌活性。实验进一步表明，即使部分破坏ENL与RNA的相互作用，也能在小鼠模型中有效抑制白血病的发生。这些发现确立了RNA作为致癌凝聚物功能辅助因子的关键角色，为癌症治疗提供了新的作用靶点。References:Budinich K A, Yao X, Gong C, et al. RNA reinforces condensate nucleation on chromatin to amplify oncogenic transcription[J]. bioRxiv, 2025: 2025.07. 29.665963.前往小宇宙评论区与主播互动
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1241-RNA强化染色质凝聚物成核并放大致癌转录
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