EPISODE · Jul 7, 2026 · 17 MIN
1243-人类衰老过程中的多组学非线性动力学
from 聊聊Sci
这项研究利用深层多组学分析技术，通过对108名受试者进行多年随访，揭示了人体衰老过程中分子变化的非线性特征。研究发现，人体并非匀速老去，绝大多数分子和微生物的波动集中在44岁和60岁这两个关键转折点。在40岁左右的更替浪潮中，代谢变化主要集中在脂质、酒精代谢及心血管疾病相关分子；而60岁左右的转变则更多涉及免疫调节、肾功能以及糖代谢的显著失调。这些发现挑战了传统的线性衰老模型，证明了衰老风险在特定生命阶段会剧烈加速。通过识别这些非线性轨迹，该研究为疾病预防和健康干预提供了精准的时间窗口和潜在靶点。References:Shen, X., Wang, C., Zhou, X. et al. Nonlinear dynamics of multi-omics profiles during human aging. Nat Aging 4, 1619–1634 (2024). https://doi.org/10.1038/s43587-024-00692-2前往小宇宙评论区与主播互动
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1243-人类衰老过程中的多组学非线性动力学
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