1251-Ovarian Spatiotemporal Atlas of Folliculogenesis

This study utilizes Slide-seq, a high-resolution spatial transcriptomics technique, to map the complex cellular landscape of the mouse ovary throughout its life cycle. Researchers developed a specialized segmentation pipeline to analyze the molecular interactions between oocytes, follicles, and corpora lutea across young and aging biological samples. The data reveal that chronological aging causes a significant breakdown in the spatiotemporal coordination of ovarian structures, even before reproductive cycles officially end. These age-related changes are marked by heightened inflammation, altered immune cell activity, and a loss of the precise timing required for healthy follicle development. Ultimately, the findings suggest that the deterioration of the multicellular niche and general tissue organization precedes the total loss of fertility in mammals.References:Lan T C T, Kochersberger A, Raichur R, et al. Aging disrupts spatiotemporal coordination in the cycling murine ovary[J]. Nature Aging, 2026: 1-23.前往小宇宙评论区与主播互动