EPISODE · Jul 12, 2026 · 22 MIN
1269-非小细胞肺癌血液蛋白质组学治疗响应分析
from 聊聊Sci
这项研究利用SomaScan和NULISA等先进的血浆蛋白质组学平台，深入分析了非小细胞肺癌患者在手术及免疫治疗前后的血液生物标志物变化。研究人员识别出了与手术切除反应、肿瘤复发风险以及免疫检查点抑制剂疗效相关的关键蛋白质特征，并发现某些炎症和免疫调节因子与患者的生存预后密切相关。通过多平台验证，该研究揭示了如IL-6、MUC16和CEACAM5等蛋白在监测治疗动态中的重要作用。这些发现证明了血浆蛋白质组学作为一种非侵入性工具，在实现肺癌精准医疗和实时监测治疗反应方面具有巨大潜力。该项工作为优化临床决策和提高患者生存率提供了新的生物学依据。References:Yaghoubi Naei V, Kilgallon A, Mendes G, et al. Dissecting non-small cell lung cancer (NSCLC) with blood proteomics—from surgical to immunotherapeutic responses[J]. npj Precision Oncology, 2026.前往小宇宙评论区与主播互动
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1269-非小细胞肺癌血液蛋白质组学治疗响应分析
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