1272-Mapping Invasive-Front Signature of Bladder Cancer

This article details a spatial transcriptomic study of non-muscle-invasive bladder cancer using high-quality en bloc resection specimens. By preserving the three-dimensional architecture of the tissue, researchers identified a distinct 15-gene signature specifically enriched at the tumor-boundary region, or invasive front. These genes are primarily associated with epithelial-mesenchymal transition and extracellular matrix remodeling, processes that facilitate cancer cell migration and invasion. Analysis of public datasets further suggests that high expression of this signature correlates with shorter survival and more advanced pathological stages. Ultimately, the study highlights how these molecular insights could improve prognostic accuracy and guide more personalized treatment strategies for bladder cancer patients.References:Yoshihara K, Urabe F, Umemori M, et al. Spatial transcriptomics of en bloc transurethral resection of bladder tumor specimens defines an invasive-front gene expression signature[J]. npj Precision Oncology, 2026.前往小宇宙评论区与主播互动