1274-IMIREG：揭示免疫参与架构与预测免疫治疗反应的转录组特征

这份研究介绍了一种名为 IMIREG 的新型转录组生物标志物，旨在提高癌症免疫检查治疗（ICB）的精准度。研究人员通过系统生物学方法，从转录因子的活性中提取出由 14 个调节子构成的特征信号，能够更精准地评估肿瘤微环境中的免疫参与度。该指标在涵盖 16 种癌症类型的 50 个临床队列中得到了验证，其预测治疗效果的准确性显著优于现有的多种标志物。分析显示，IMIREG 高表达的肿瘤处于一种“已激活但受抑制”的特殊状态，这种状态对免疫药物高度敏感，且最容易在 T 细胞与巨噬细胞协同作用时出现。研究进一步揭示，这种协同免疫状态在癌症转移阶段会大幅减弱，说明肿瘤在演进过程中存在免疫逃逸。最后，针对三阴性乳腺癌的动态追踪证实，IMIREG 可作为药效监测指标，在治疗早期即可预测患者的病理完全缓解情况。References:Lawal B, Sharma R, Gupta A, et al. IMIREG: a lineage-resolved regulon signature unveiling immune engagement archetypes and predicting immunotherapy response across diverse cancers[J]. NPJ Precision Oncology, 2026.前往小宇宙评论区与主播互动

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1274-IMIREG：揭示免疫参与架构与预测免疫治疗反应的转录组特征

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