EPISODE · Jul 14, 2026 · 27 MIN
1277-溶质载体家族在癌症代谢中的调控与治疗策略
from 聊聊Sci
溶质载体 (SLC) 转运蛋白家族在调节癌症代谢、支持肿瘤增殖及免疫逃逸中发挥着核心作用。本文综述了 GLUT1、LAT1 和 MCT4 等关键成员如何通过重编程碳水化合物、氨基酸和脂质的运输来维持恶性生长。这些转运蛋白的结构多样性和功能特异性使其成为极具潜力的临床治疗靶点。目前，诸如 BAY-876 和 JPH203 等选择性抑制剂在临床前研究中已显示出显著疗效。通过将 SLC 抑制剂与传统化疗或免疫疗法相结合，研究者有望克服肿瘤耐药性。最终，针对不同癌症代谢特征的个性化策略与生物标志物的开发，将是实现临床转化的关键。References:Zhang X, Feng J, Cai X, et al. The regulatory roles and therapeutic strategies of the solute carrier transporters in cancer metabolism[J]. npj Precision Oncology, 2026.前往小宇宙评论区与主播互动
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1277-溶质载体家族在癌症代谢中的调控与治疗策略
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