1292-CODEX-CNS：阿尔茨海默症脑部空间蛋白质组学分析

这篇文章介绍了一种名为 CODEX-CNS 的创新型多重蛋白质成像技术，专门用于精确绘制人类大脑的分子图谱。研究人员利用该技术分析了阿尔茨海默病（AD）患者与健康对照组的大脑样本，成功克服了脑组织高背景荧光的干扰，实现了对单细胞水平及其空间微环境的深度解析。通过对七十多万个细胞的观察，该研究揭示了小胶质细胞在病理状态下的异质性，并识别出一种与淀粉样蛋白斑块密切相关的特定细胞亚群。这项工作不仅阐明了细胞间的空间相互作用如何驱动疾病进展，还为神经科学研究提供了一个能够同时检测数十种蛋白质的高分辨率分析平台。References:Sanchez-Molina P, Rosmus D D, Brownell D, et al. Spatial proteomic analysis in human Alzheimer’s disease brains enables identification of microenvironment-dependent microglial cell states[J]. Nature Neuroscience, 2026: 1-16.前往小宇宙评论区与主播互动

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1292-CODEX-CNS：阿尔茨海默症脑部空间蛋白质组学分析

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