EPISODE · Jul 17, 2026 · 18 MIN
1294-后脑类器官发育多组学图谱与形态发生素筛选
from 聊聊Sci
这份研究通过建立单细胞多组学图谱，深入探讨了人类中脑和后脑类器官的发育机制与工程化方法。研究团队对比了现有的两种培养方案，利用单细胞转录组和染色质可及性测序技术，揭示了调控神经元分化的基因监管网络。通过结合MERSCOPE空间转录组分析和CRISPR基因干扰实验，作者验证了关键转录因子在确定细胞区域特征中的作用。此外，研究还进行了一项涵盖48种条件的形态发生素筛选，成功诱导出以往模型中缺失的延髓甘氨酸能神经元和小脑谷氨酸能神经元。该成果不仅完善了后脑发育的调控模型，也为建立更高仿真度的体外疾病模型提供了精确的指导。References:Azbukina N, He Z, Lin H C, et al. Single-cell multi-omic atlas and morphogen screening informs midbrain and hindbrain organoid engineering[J]. Nature Neuroscience, 2026: 1-11.前往小宇宙评论区与主播互动
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1294-后脑类器官发育多组学图谱与形态发生素筛选
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