EPISODE · Jul 17, 2026 · 23 MIN
1295-人脑动脉瘤的细胞图谱与纤维化机制
from 聊聊Sci
这项研究通过单细胞和空间转录组学技术，构建了首个详尽的人类脑动脉瘤细胞图谱。研究人员对比了患者动脉瘤组织与健康血管，发现动脉瘤在发展过程中伴随着维持血管结构的平滑肌细胞大量流失。与此同时，一种表现出致病特征的活化周皮成纤维细胞异常增多，并重新占据了受损的血管壁。这些成纤维细胞与特定巨噬细胞之间的信号交互，共同引发了血管壁的纤维化与炎症反应。该成果揭示了驱动脑动脉瘤进展的关键分子机制，为预防血管破裂和开发新型临床治疗手段提供了重要依据。References:Wang J C, Kim C N, Bhalla S, et al. Cerebrovascular vulnerability and fibrosis in human brain aneurysms[J]. Nature neuroscience, 2026: 1-12.前往小宇宙评论区与主播互动
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