130. Mast Cell Activation Syndrome - Discussing How Pathogenic Microbes Can Activate Mast Cells & Addressing Histamine-Producing and Histamine-Degrading Probiotics

In this episode, we explore the role of probiotics in managing histamine levels and mast cell activation syndrome (MCAS), particularly in the context of rebuilding the gut microbiome. We discuss which probiotic strains could contribute to symptoms (in the short term) due to their histamine-producing properties, such as Lactobacillus casei and Lactobacillus reuteri, and we highlight beneficial strains that degrade histamine, including Lactobacillus plantarum. Topics: 1. Introduction to Histamine and Mast Cell Activation - Overview of histamine and mast cell activation syndrome (MCAS) - Understanding histamine production 2. Breakdown of White Blood Cells (WBCs) - Origin of WBCs from hematopoietic stem cells in the bone marrow - Categories of WBCs: granulocytes, monocytes, and lymphocytes 3. Examination of Granulocytes - Neutrophils: Role in bacterial infections - Eosinophils: Role in allergic reactions and parasitic infections - Basophils: Involvement in inflammatory and allergic responses through histamine release - Mast Cells: Similarities to basophils, maturation in tissues, and histamine release 4. Examination of Agranulocytes - Monocytes: Phagocytic function and differentiation into macrophages and dendritic cells - Lymphocytes: - T cells: Subtypes and their functions (helper T cells, cytotoxic T cells, regulatory T cells) - B cells: Antibody-mediated immunity - NK cells 5. Mast Cells vs. Basophils - Location and function comparison - Importance in histamine production 6. Mast Cell Activation Syndrome (MCAS) - Triggers of MCAS (infections, environmental exposures, dietary factors, genetic predispositions) - Focus on addressing root causes (lyme?, mold?, candida?, SIBO?, ...) 7. Probiotic Use in the Context of MCAS - Probiotics and pathogenic microbes in the context of mast cell activation 8. Example: Candida and Mast Cell Interaction - Recognition of Candida by mast cells through pattern recognition receptors (PRRs) - Activation pathways and release of histamine and other inflammatory mediators 9. Probiotics and Histamine Production - Probiotic strains that produce histamine - Lactobacillus casei, - Lactobacillus reuteri, - Lactobacillus bulgaricus... - Probiotic strains that do not produce histamine and/or degrade histamine - Bifidobacterium infantis, - Bifidobacterium longum, - Bifidobacterium bifidum, - Bifidobacterium breve, - Lactobacillus plantarum, - Lactobacillus rhamnosus, - Lactobacillus gasseri, - Lactobacillus salivarius Thank you to our episode sponsors: ⁠⁠⁠Liver Medic⁠⁠⁠⁠ Use code Chloe20 to save 20% on ⁠⁠⁠⁠⁠"Leaky Gut Repair"⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠Brendan's YouTube Channel⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠https://x.com/livermedic⁠⁠⁠⁠⁠ Tremetes, LLC Use code CHLOE15 to get 15% off Tremetes' Turkey Tail Thanks for tuning in! Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more!