EPISODE · Jul 19, 2026 · 26 MIN
1301-DDL-357：一种改善阿尔茨海默病小鼠记忆的载脂蛋白增强剂
from 聊聊Sci
这份研究介绍了一种针对阿尔茨海默病（AD）的创新疗法，重点在于增强大脑中分泌型簇集素（sCLU）的水平。研究团队通过高通量筛选和化学优化，开发出了名为 DDL-357 的新型小分子BET抑制剂，该药物具备良好的脑渗透性。在小鼠模型实验中，口服 DDL-357 显著提升了sCLU含量，并有效降低了磷酸化 tau 蛋白水平，从而改善了患病小鼠的记忆和学习能力。蛋白质组学分析进一步证实，该药物能增强与线粒体功能、突触可塑性及蛋白质清除相关的神经保护蛋白。这项成果为治疗阿尔茨海默病及其他蛋白质病变引起的神经退行性疾病提供了新的潜在候选药物。References:Cohn W, Campagna J, Wi D, et al. Discovery of a small molecule secreted clusterin enhancer that improves memory in Alzheimer’s disease mice[J]. npj Drug Discovery, 2025, 2(1): 7.前往小宇宙评论区与主播互动
Embed this episode
Ready to play
1301-DDL-357：一种改善阿尔茨海默病小鼠记忆的载脂蛋白增强剂
0:00
26:57
1×
No transcript for this episode yet
Similar Episodes
No similar episodes found.
Similar Podcasts
Forfeiture Book Review: Ecocide and Sci-Fi
JP et al.
A whizz bang review of the complex themes in the new ecological Sci-Fi novel, FORFEITURE by JP Nebra
Deep Dream State
Neural Nets And Pretty Patterns
Deep Dream State is a full-cast dystopian sci-fi and desire horror audio drama by Neural Nets and Pretty Patterns. As the originating work of desire horror, it locates the uncanny inside wanting itself. While conventional horror positions you against a threat, desire horror implicates you in it. The horror emerges from recognition: the realization of why characters stay, and why surrender feels like relief. Since 2017, the show has used research in dream science, surveillance studies, behavioral economics, and advertising technology to examine systems of control through immersive sound design and full-cast performance.
Frequently Asked Questions
How long is this episode of 聊聊Sci?
This episode is 26 minutes long.
When was this 聊聊Sci episode published?
This episode was published on July 19, 2026.
Can I download this 聊聊Sci episode?
Yes. Use the download control on the episode player to save the publisher-provided media file.
URL copied to clipboard!