EPISODE · Jul 20, 2026 · 24 MIN
1310-可扩展粒单核系祖细胞：一种工程化骨髓细胞治疗平台
from 聊聊Sci
该研究开发了一种创新的工程化骨髓细胞疗法平台，通过特定化学条件实现了粒细胞-单核细胞祖细胞（GMPs）在体外的大规模克隆扩增。研究人员发现，抑制骨髓过氧化物酶（MPO）是解锁这些祖细胞增殖潜力的关键，使其能保持分化能力并高效接受基因工程改造。相较于传统巨噬细胞，这些扩增的GMPs在输注后能更好地植入造血龛并产生持久的体内免疫输出，有效抑制血液肿瘤和实体瘤。此外，研究引入了CAR-Fc架构，通过招募受体免疫细胞协同作战，克服了异体移植中的组织相容性障碍。这项工作为可扩展、可编程的免疫细胞治疗提供了一种全新的上游细胞来源。References:Yue S, Guo Z, Pan C, et al. Expansion and CAR engineering of granulocyte-monocyte progenitors for cellular immunotherapy[J]. Cell, 2026.前往小宇宙评论区与主播互动
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1310-可扩展粒单核系祖细胞：一种工程化骨髓细胞治疗平台
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