EPISODE · Jul 23, 2026 · 28 MIN
1323-胃癌化疗联合免疫治疗的T细胞克隆动态研究
from 聊聊Sci
这项研究通过对晚期胃癌患者进行连续活检和单细胞测序，揭示了化疗联合免疫治疗产生持久疗效的免疫机制。研究发现，长生存期患者（慢进展者）在治疗过程中能够维持具有肿瘤反应性且呈前体耗竭状态的特定T细胞克隆。这些关键的T细胞克隆在治疗前已存在于外周血中，并在免疫治疗后有效浸润至肿瘤组织。此外，肿瘤微环境内B细胞的增加及其与T细胞间的共刺激信号交互，为这些抗癌T细胞的持久存在提供了重要支持。该成果为预测胃癌免疫治疗效果提供了生物标志物，并为优化治疗方案提供了理论依据。References:Wright S J, Kang S, An M, et al. Differential T cell clonal dynamics underlie outcomes to frontline chemoimmunotherapy in advanced gastric cancer[J]. Cell Reports Medicine, 2025.前往小宇宙评论区与主播互动
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1323-胃癌化疗联合免疫治疗的T细胞克隆动态研究
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