EPISODE · Jul 23, 2026 · 25 MIN
1325-靶向FAM3D蛋白缓解动脉粥样硬化研究
from 聊聊Sci
这项研究揭示了细胞因子样蛋白 FAM3D 在加速动脉粥样硬化中的关键作用，并提出其作为治疗靶点的潜力。研究发现，人体循环系统中 FAM3D 水平的升高与病发率密切相关，该蛋白通过脂质依赖和非脂质依赖的双重机制加剧病情。在肠道中，它通过 FPR1 受体促进 MTTP 的表达，从而增强脂质吸收并引发高脂血症；在血管中，它则诱发平滑肌细胞表型转化。实验证明，使用单克隆抗体靶向清除 FAM3D 能显著减轻小鼠的血管病变。这一发现为应对现有降脂疗法无法完全消除的心血管残留风险提供了新的干预策略。References:Zhu S, Zhu M, Fan F, et al. Targeting cytokine-like protein FAM3D alleviates atherosclerosis[J]. Cell Reports Medicine, 2026.前往小宇宙评论区与主播互动
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1325-靶向FAM3D蛋白缓解动脉粥样硬化研究
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