EPISODE · Jul 27, 2026 · 14 MIN
1341-快速传导机械伤害感受器对疼痛环路的调节作用
from 聊聊Sci
这项研究通过对小鼠感官神经元进行光遗传学筛选，识别出两类对疼痛感知至关重要的快速传导机械伤害感受器（Aδ-HTMRs）。这些神经元不仅分布在皮肤中，还广泛延伸至骨骼、关节和肾脏等多种内部器官，专门负责探测可能导致组织损伤的高强度压力。研究发现，这些髓鞘化神经元拥有独特的解剖结构，能够在中枢神经系统内形成复杂的**“巢状”突触连接**。通过同时激活局部脊髓反射通路和上行脑部回路，它们能够驱动极速的肢体撤回反应并引发负面的情感避恶。该成果通过明确Aδ-HTMRs在物理性疼痛中的核心作用，为开发新型镇痛药物提供了关键的生物学基础。References:Lezgiyeva K, Liu J, Nguyen K, et al. Fast-conducting mechanonociceptors uniquely engage reflexive and affective pain circuitry to drive protective responses[J]. bioRxiv, 2025: 2025.11. 11.687663.前往小宇宙评论区与主播互动
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