EPISODE · Jul 27, 2026 · 24 MIN
1342-TGF-β1诱导的内皮胞吞作用驱动衰老期血脑屏障渗漏
from 聊聊Sci
这项研究揭示了老龄化导致血脑屏障（BBB）受损的核心机制，指出屏障渗漏并非始于紧密连接的破坏，而是由于内皮细胞囊泡转运（transcytosis）的增加。研究发现，随着年龄增长，大脑和血液中的TGF-β1蛋白水平升高，通过激活特定的信号通路抑制了内皮细胞中关键转运蛋白Mfsd2a的表达。这种抑制作用导致内皮细胞内的囊泡运输变得活跃，使得血浆蛋白等有害物质更容易渗透进大脑。实验证明，通过基因手段恢复Mfsd2a或利用药物阻断TGF-β通路，可以有效修复老龄小鼠的血脑屏障完整性。最终，这种治疗干预不仅减少了血管渗漏，还显著改善了高龄个体的认知功能。这些发现为治疗与衰老相关的神经血管疾病提供了新的潜在靶点。References:Fang C, Ma Y, Wei P, et al. TGF-β1-induced endothelial transcytosis drives blood-brain barrier leakage during aging[J]. Neuron, 2026.前往小宇宙评论区与主播互动
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1342-TGF-β1诱导的内皮胞吞作用驱动衰老期血脑屏障渗漏
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