1343-人体与癌症空间蛋白质组学图谱 episode artwork

EPISODE · Jul 27, 2026 · 25 MIN

1343-人体与癌症空间蛋白质组学图谱

from 聊聊Sci

这篇文章介绍了一项发表于2026年的重大研究,科学家们通过质谱技术构建了首个涵盖人体全身组织及多种癌症的蛋白质组定量图谱。该研究通过分析两千多个样本,成功绘制了从胎儿、健康成年人到肿瘤及其配对组织的蛋白质表达轨迹,识别出超过一万三千种蛋白质。通过对比不同生理与病理状态,研究者发现了组织特异性的蛋白分布规律,这为理解器官发育和癌症演变提供了关键数据。此外,该资源还能有效指示药物毒性风险,并助力抗癌药物的老药新用。这项工作不仅扩充了人类蛋白质库,也为精准医疗和新药研发提供了数字导航工具。References:Yue L, Jiang W, Li S, et al. Spatial distribution of the proteome in the human body and in cancers[J]. Nature, 2026: 1-10.前往小宇宙评论区与主播互动

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