EPISODE · Jul 27, 2026 · 20 MIN
1345-急性髓系白血病染色质景观与表观遗传异质性
from 聊聊Sci
这项研究通过对1,563名急性髓系白血病（AML）患者的大规模染色质开放性分析，构建了名为eCHROMA的多组学资源库。研究者利用ATAC-seq技术将AML重新划分为16个独特的表观遗传亚组，揭示了基因组学以外的致病机制与病理异质性。这些亚组不仅在驱动突变、细胞分化轨迹及超增强子图谱上表现出高度特异性，还与患者的临床预后和药物敏感性密切相关。通过单细胞水平的验证，研究进一步阐明了由关键转录因子驱动的基因调节网络如何塑造不同亚组的细胞身份。总之，该研究证明了基于染色质特征的分类在精准医疗和风险分层中具有超越传统遗传学分类的独立预测价值。References:Ochi Y, Liew-Littorin M, Nannya Y, et al. Chromatin landscape and epigenetic heterogeneity of acute myeloid leukaemia[J]. Nature, 2026: 1-11.前往小宇宙评论区与主播互动
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1345-急性髓系白血病染色质景观与表观遗传异质性
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