EPISODE · Jul 29, 2026 · 12 MIN
1351-GABA抑制肿瘤三级淋巴结构功能与免疫治疗耐药研究
from 聊聊Sci
这项研究揭示了癌症治疗中三级淋巴结构（TLS）失效的核心机制。研究指出，肿瘤细胞分泌的氨基丁酸（GABA）会充当免疫抑制剂，直接削弱相邻免疫细胞的活性。这种化学信号会阻碍B细胞的增殖与抗体分泌，导致患者对免疫检查点阻断疗法产生耐药性。通过实验验证，抑制GABA通路能够重新激活免疫微环境，显著增强免疫治疗对实体瘤的打击效果。这一发现为改善抗癌疗效并克服免疫耐药性提供了全新的药物干预方向。References:Salgia N J, Muhitch J B. Your neighbors matter: Adjacent cancer cells dampen TLS function[J]. Cancer Cell, 2026.前往小宇宙评论区与主播互动
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1351-GABA抑制肿瘤三级淋巴结构功能与免疫治疗耐药研究
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