EPISODE · Jul 29, 2026 · 27 MIN
1352-Menin抑制剂在骨髓增殖性肿瘤中的治疗作用
from 聊聊Sci
这篇文章探讨了Menin抑制剂在治疗骨髓增殖性肿瘤（MPNs）中的潜力和机制。研究发现，Menin蛋白是维持巨核细胞祖细胞增殖的关键因子，而抑制该蛋白能有效阻断病理性巨核细胞的产生。通过使用临床药物revumenib，研究者在多种小鼠模型和患者样本中成功抑制了骨髓纤维化并使血细胞计数恢复正常。此外，实验证明Menin抑制剂通过下调 MEF2C 等核心基因发挥作用，且与现有药物鲁索替尼具有显著的协同治疗效应。这些发现为临床应用Menin抑制剂缓解骨髓纤维化这一医学难题提供了坚实的理论依据。References:Wen J, Cotton A, Mehmood R, et al. Menin-dependent megakaryocyte proliferation and fibrosis in myeloproliferative neoplasms[J]. Cancer Cell, 2026.前往小宇宙评论区与主播互动
Embed this episode
Ready to play
1352-Menin抑制剂在骨髓增殖性肿瘤中的治疗作用
0:00
27:18
1×
No transcript for this episode yet
Similar Episodes
No similar episodes found.
Similar Podcasts
Forfeiture Book Review: Ecocide and Sci-Fi
JP et al.
A whizz bang review of the complex themes in the new ecological Sci-Fi novel, FORFEITURE by JP Nebra
Deep Dream State
Neural Nets And Pretty Patterns
Deep Dream State is a full-cast dystopian sci-fi and desire horror audio drama by Neural Nets and Pretty Patterns. As the originating work of desire horror, it locates the uncanny inside wanting itself. While conventional horror positions you against a threat, desire horror implicates you in it. The horror emerges from recognition: the realization of why characters stay, and why surrender feels like relief. Since 2017, the show has used research in dream science, surveillance studies, behavioral economics, and advertising technology to examine systems of control through immersive sound design and full-cast performance.
Frequently Asked Questions
How long is this episode of 聊聊Sci?
This episode is 27 minutes long.
When was this 聊聊Sci episode published?
This episode was published on July 29, 2026.
Can I download this 聊聊Sci episode?
Yes. Use the download control on the episode player to save the publisher-provided media file.
URL copied to clipboard!