EPISODE · Jul 30, 2026 · 17 MIN
1358-GABA介导肿瘤免疫治疗耐药及TLS功能障碍
from 聊聊Sci
这份研究探讨了肿瘤分泌的氨基丁酸（GABA）如何导致携带三级淋巴结构（TLS）的癌症患者对免疫治疗产生耐药性。通过对肾透明细胞癌和肉瘤的多组学分析，研究人员发现非响应者体内的GABA水平显著升高，这种神经递质会诱发B细胞功能障碍并抑制其免疫活性。空间转录组学显示，靠近GABA分泌细胞的淋巴结构表现出代谢重编程和成熟受阻。在动物模型中，使用药物阻断GABA合成能显著增强抗PD-1疗法的效果，并促进免疫细胞浸润。该成果揭示了肿瘤通过“神经模拟”逃避免疫监管的新机制，为克服免疫检查点抑制剂耐药性提供了潜在的治疗靶点。References:Hernández-Verdin I, Calvez A, Sun C M, et al. GABA promotes resistance to immunotherapy in patients with TLS-positive tumors[J]. Cancer Cell, 2026.前往小宇宙评论区与主播互动
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1358-GABA介导肿瘤免疫治疗耐药及TLS功能障碍
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