1359-Modern Perspectives on Alzheimer’s Pathogenesis

This comprehensive review outlines recent scientific breakthroughs in the study of Alzheimer’s disease, covering its biological origins and modern treatment options. Researchers describe how the buildup of amyloid-β and tau proteins disrupts brain function, while emphasizing the critical role of the APOE gene and the immune system in driving these pathologies. The text also details the evolution of biomarkers, such as blood tests and advanced imaging, which allow for earlier diagnosis and more precise disease staging. Furthermore, it highlights a new era of disease-modifying therapies, including lecanemab and donanemab, which demonstrate that removing brain plaques can slow cognitive decline. Ultimately, the authors argue that these collective discoveries are shifting the medical paradigm toward a future where the disease is both treatable and preventable.References:Rudman M D, Ulrich J D, Holtzman D M. Recent advances in Alzheimer’s disease: From molecular mechanisms to therapeutic strategies[J]. Cell, 2026, 189(14): 4193-4224.前往小宇宙评论区与主播互动