EPISODE · Jul 31, 2026 · 19 MIN
1361-跨物种红细胞生态位的空间转录组图谱
from 聊聊Sci
这项研究利用空间转录组学技术揭示了小鼠与人类在红细胞生成微环境（即红系造血岛）结构上的显著物种差异。在小鼠模型中，研究确认了表达 C1q 的巨噬细胞是造血岛的核心，并负责清理脱出的细胞核以支持红细胞成熟。相比之下，人类的红系造血岛表现出独特的巨噬细胞非依赖性特征，其结构完整性主要依靠黏附分子 ICAM4 来维持。研究还发现，这种人类特有的红细胞集群在骨髓类疾病中会遭到破坏，但可以通过治疗得到恢复。这些发现挑战了传统的造血生态位模型，为理解不同物种间红细胞发育的动态差异提供了重要框架。References:Han X, Ren K, Wang P, et al. Spatial transcriptomic analyses highlight distinct erythroid niches in mice and humans[J]. Nature Genetics, 2026: 1-12.前往小宇宙评论区与主播互动
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1361-跨物种红细胞生态位的空间转录组图谱
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