EPISODE · Aug 3, 2026 · 19 MIN
1377-结肠癌致癌突变与基质信号调节的细胞极化表型图谱
from 聊聊Sci
这项研究通过对一千多个结肠类器官进行单细胞分析，揭示了结直肠癌中细胞内在突变与外部微环境信号如何共同调控上皮细胞的命运。研究发现，结肠干细胞存在于一个连续的表型景观中，其中成纤维细胞通过TGF-β1和YAP通路诱导产生缓慢循环的复兴干细胞（revCSC），而癌基因则驱动产生高增殖的促癌干细胞（proCSC）。实验证明，APC缺失与KRAS突变具有协同作用，能够阻断细胞对微环境调节信号的响应。这种机制使上皮细胞脱离稳态调控，从而被困在促癌的干细胞状态中。尽管癌基因占据主导地位，但在抑制PI3K通路并加强TGF-β1信号的情况下，结直肠癌细胞仍能向复兴状态转化。总之，该文绘制了一幅由致癌突变和基质配体竞争决定的结肠上皮分化蓝图。References:Qin X, Rodriguez F C, Sufi J, et al. An oncogenic phenoscape of colonic stem cell polarization[J]. Cell, 2023, 186(25): 5554-5568. e18.前往小宇宙评论区与主播互动
Embed this episode
Ready to play
1377-结肠癌致癌突变与基质信号调节的细胞极化表型图谱
0:00
19:15
1×
No transcript for this episode yet
Similar Episodes
No similar episodes found.
Similar Podcasts
Forfeiture Book Review: Ecocide and Sci-Fi
JP et al.
A whizz bang review of the complex themes in the new ecological Sci-Fi novel, FORFEITURE by JP Nebra
Deep Dream State
Neural Nets And Pretty Patterns
Deep Dream State is a full-cast dystopian sci-fi and desire horror audio drama by Neural Nets and Pretty Patterns. As the originating work of desire horror, it locates the uncanny inside wanting itself. While conventional horror positions you against a threat, desire horror implicates you in it. The horror emerges from recognition: the realization of why characters stay, and why surrender feels like relief. Since 2017, the show has used research in dream science, surveillance studies, behavioral economics, and advertising technology to examine systems of control through immersive sound design and full-cast performance.
Frequently Asked Questions
How long is this episode of 聊聊Sci?
This episode is 19 minutes long.
When was this 聊聊Sci episode published?
This episode was published on August 3, 2026.
Can I download this 聊聊Sci episode?
Yes. Use the download control on the episode player to save the publisher-provided media file.
URL copied to clipboard!