EPISODE · Aug 3, 2026 · 22 MIN
1378-上皮-间质转化：肿瘤细胞可塑性与演进的核心驱动力
from 聊聊Sci
这篇文章详细阐述了上皮-间质转化（EMT）在癌症演变中的核心作用，强调它并非简单的二元切换，而是一个具有高度可塑性的状态连续谱。研究表明，EMT 不仅驱动肿瘤细胞的浸润与转移，还通过重塑表观遗传特征，在肿瘤启动、免疫逃逸以及耐药性产生中发挥关键作用。作者区分了类似胚胎发育的“侵袭性”路径与类似组织修复的“炎症性”路径，指出这些多样化的细胞状态共同构成了肿瘤内部的异质性。针对 EMT 带来的挑战，文中探讨了如靶向蛋白质降解（PROTACs）、诱导铁死亡以及细胞重编程等新兴治疗策略。最后，文章指出通过结合逻辑门 CAR-T 疗法与化疗的组合手段，有望克服由细胞动态转化导致的治疗耐受，为癌症精准治疗提供新方向。References:Jimenez-Castaño R, Nieto M A. Epithelial-to-mesenchymal transition as a central driver of tumor cell plasticity[J]. Nature Cancer, 2026: 1-16.前往小宇宙评论区与主播互动
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1378-上皮-间质转化：肿瘤细胞可塑性与演进的核心驱动力
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