138: Social exposome and dementia in Latin America

Migeot J et al., Nature Communications - Large multicenter study linking a multidimensional social exposome (education, food insecurity, finances, healthcare access, childhood experiences) to cognition, function, neuropsychiatric symptoms, brain atrophy and connectivity in AD, FTLD and healthy aging across six Latin American countries. Key terms: social exposome, dementia, Latin America, brain connectivity, food insecurity. Study Highlights:The study evaluated 2,211 participants across six Latin American countries using a validated multidimensional social exposome (MSE) score spanning education, food insecurity, financial status, assets, healthcare access, childhood labor and traumatic events. Greater adverse MSE correlated with poorer cognition in healthy aging and with lower cognitive and functional performance and increased neuropsychiatric symptoms in Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD). Higher MSE adversity associated with reduced gray matter and altered resting-state functional connectivity in fronto-temporo-limbic and cerebellar regions. Food insecurity, financial resources, subjective socioeconomic status and access to healthcare emerged as key predictors and cumulative MSE outperformed individual factors. Conclusion:A cumulative, lifespan multidimensional social exposome strongly associates with worse clinical, cognitive and brain outcomes in aging and dementia across Latin America, highlighting the need for prevention and interventions that address social disparities. Music:Enjoy the music based on this article at the end of the episode. Article title:Social exposome and brain health outcomes of dementia across Latin America First author:Migeot J Journal:Nature Communications DOI:10.1038/s41467-025-63277-6 Reference:Migeot J, Pina-Escudero SD, Hernandez H, et al. Social exposome and brain health outcomes of dementia across Latin America. Nature Communications. 2025;16:8196. doi:10.1038/s41467-025-63277-6 License:This episode is based on an open-access article published under the Creative Commons Attribution 4.0 International License (CC BY 4.0) – https://creativecommons.org/licenses/by/4.0/ Support:Base by Base – Stripe donations: https://donate.stripe.com/7sY4gz71B2sN3RWac5gEg00 Official website https://basebybase.com On PaperCast Base by Base you'll discover the latest in genomics, functional genomics, structural genomics, and proteomics. Episode link: https://basebybase.com/episodes/social-exposome-and-brain-health-outcomes-of-dementia-across-latin-america QC:This episode was checked against the original article PDF and publication metadata for the episode release published on 2025-09-15. QC Scope:- article metadata and core scientific claims from the narration- excludes analogies, intro/outro, and music- transcript coverage: Audited the transcript sections describing the MSE concept, lifespan-domain assessment, reverse-causation controls, neuroimaging findings (GMV and rs-fMRI connectivity), cross-site harmonization, and broader implications for dementia risk and social disparities.- transcript topics: Multidimensional social exposome (MSE) concept; Lifespan-domain scoring and 10 domains; Reverse causation controls and SEM; Brain structural correlates: gray matter volume reductions in AD/FTLD; Functional connectivity and compensatory hyperconnectivity; Scanner harmonization and sensitivity analyses QC Summary:- factual score: 10/10- metadata score: 10/10- supported core claims: 6- claims flagged for review: 0- metadata checks passed: 4- metadata issues found: 0 Metadata Audited:- article_doi- article_title- article_journal- license Factual Items Audited:- MSE is a lifespan, multi-domain...