EPISODE · Aug 5, 2026 · 23 MIN
1386-原位生物正交点击技术提升抗体偶联药物疗效
from 聊聊Sci
这篇研究论文介绍了一种名为“抗体-ADC点击”的创新医疗平台，旨在解决传统抗体偶联药物（ADC）在治疗异质性肿瘤时面临的耐药难题。研究人员利用生物正交点击化学技术，通过先后注射分别携带特定化学基团的治疗性抗体与ADC，使其在生物体内自动精准“锁合”成功能性复合物。这种模块化方法显著增强了药物在HER2低表达或表达不均的肿瘤组织中的靶向聚集与细胞内吞效率，从而提升了治疗效果。实验证明，该策略在多种耐药模型中表现出优于标准单药或简单联合用药的抗肿瘤活性**。此外，该技术无需复杂的抗体基因重组，为应对不同癌症类型的治疗耐药性提供了一种灵活且高效的临床转化方案。References:Simó C, Vanover A C, D’Oliveira Albanus R, et al. Modular in vivo antibody–ADC click to reverse drug resistance in tumours[J]. Nature, 2026: 1-10.前往小宇宙评论区与主播互动
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1386-原位生物正交点击技术提升抗体偶联药物疗效
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