EPISODE · Aug 6, 2026 · 19 MIN
1395-靶向可成药激酶治疗神经病理性疼痛
from 聊聊Sci
这篇文章探讨了针对蛋白激酶开发非阿片类药物以治疗神经病理性疼痛的最新进展。研究指出，激酶在调节轴突变性、神经炎症和异常突触信号等病理过程中起着核心作用。作者详细分析了包括p38 MAPK、AMPK和EphB在内的多种激酶目标，并评估了如度洛西汀和二甲双胍等药物的临床潜力。尽管一些抑制剂在缓解机械痛敏和热痛觉过敏方面表现出色，但该领域仍面临脱靶毒性和药物选择性等挑战。总之，该综述强调了激酶靶向疗法是解决阿片类药物危机并满足慢性疼痛治疗需求的重要科研方向。References:Benson H, Kaur K, Ahmed M S. Targeting druggable kinases in neuropathic pain[J]. npj Drug Discovery, 2026, 3: 22.前往小宇宙评论区与主播互动
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1395-靶向可成药激酶治疗神经病理性疼痛
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