EPISODE · Aug 9, 2026 · 28 MIN
1410-BMP7-TGM2轴在子痫前期发病与防治中的作用
from 聊聊Sci
该研究通过多维分析揭示了BMP7-TGM2信号轴在先兆子痫（PE）发病中的核心作用。研究发现，先兆子痫患者胎盘中的BMP7显著减少，导致其下游靶点TGM2异常升高。这种失衡会抑制滋养层细胞的迁移与侵袭能力，进而阻碍胎盘的正常发育。通过小鼠模型实验证明，补充重组BMP7蛋白或抑制TGM2活性能够显著缓解高血压及胎盘损伤等病理症状。分子机制层面，BMP7通过ALK2/3-SMAD1/5/9-SMAD4通路下调TGM2的表达。该成果不仅阐明了胎盘发育受阻的新机制，还为先兆子痫的预防与临床治疗提供了潜在的药物候选靶点。References:Ding Q, Liu M, Zhao B, et al. Role of the trophoblastic BMP7-TGM2 axis in the pathogenesis and prevention of preeclampsia[J]. Cell Death & Disease, 2026.前往小宇宙评论区与主播互动
Embed this episode
Ready to play
1410-BMP7-TGM2轴在子痫前期发病与防治中的作用
0:00
28:55
1×
No transcript for this episode yet
Similar Episodes
No similar episodes found.
Similar Podcasts
Forfeiture Book Review: Ecocide and Sci-Fi
JP et al.
A whizz bang review of the complex themes in the new ecological Sci-Fi novel, FORFEITURE by JP Nebra
Deep Dream State
Neural Nets And Pretty Patterns
Deep Dream State is a full-cast dystopian sci-fi and desire horror audio drama by Neural Nets and Pretty Patterns. As the originating work of desire horror, it locates the uncanny inside wanting itself. While conventional horror positions you against a threat, desire horror implicates you in it. The horror emerges from recognition: the realization of why characters stay, and why surrender feels like relief. Since 2017, the show has used research in dream science, surveillance studies, behavioral economics, and advertising technology to examine systems of control through immersive sound design and full-cast performance.
Frequently Asked Questions
How long is this episode of 聊聊Sci?
This episode is 28 minutes long.
When was this 聊聊Sci episode published?
This episode was published on August 9, 2026.
Can I download this 聊聊Sci episode?
Yes. Use the download control on the episode player to save the publisher-provided media file.
URL copied to clipboard!