1412-IGFBP5+ Endothelial Drives Colorectal Cancer Metastasis

This research article examines how a specific protein, IGFBP5, secreted by endothelial cells, facilitates the spread of colorectal cancer to the liver. By analyzing single-cell RNA sequencing data, the authors identified that vascular invasion is driven by a specialized subpopulation of cells that remodel the tumor microenvironment. The study demonstrates that IGFBP5 binds to the ITGB3 receptor on cancer cells, triggering the PI3K/AKT signaling pathway to enhance tumor growth and mobility. Experimental results from organoids and animal models confirm that this molecular interaction weakens the vascular barrier, allowing malignant cells to enter the bloodstream more effectively. Ultimately, the findings suggest that targeting the IGFBP5/ITGB3 axis could provide a new therapeutic strategy to prevent liver metastasis and improve patient survival rates.References:Maimaitiming N, Deng Y, Liu H, et al. IGFBP5 derived from endothelial cells drive vascular invasion and liver metastasis of colorectal cancer by activating the ITGB3/PI3K/AKT Axis[J]. Cell Death & Disease, 2026.前往小宇宙评论区与主播互动