1437-MIF-p38-GSDMD in UVB-Induced Cutaneous Lupus

This study identifies a novel MIF-p38-GSDMD inflammatory loop that drives cutaneous lupus erythematosus (CLE) following UVB exposure. Using single-cell transcriptomics and lupus-prone mouse models, researchers discovered that UVB triggers a ribotoxic stress response in keratinocytes, leading to the p38-mediated upregulation of NLRP3 and GSDMD-dependent pyroptosis. This process causes the unconventional release of macrophage migration inhibitory factor (MIF) through cellular pores, which then binds to CD74 receptors to further amplify the inflammatory cycle. The study demonstrates that disrupting this feedback loop via gene silencing or innovative microneedle patches loaded with MIF inhibitors effectively reduces skin lesions and epidermal hyperplasia. These findings position keratinocyte-derived MIF as a primary driver of photosensitivity and a promising target for localized, minimally invasive therapies.References:Guo C, Luo S, Luo J, et al. A MIF-p38-GSDMD inflammatory loop in keratinocytes underlies UVB-induced cutaneous lupus[J]. Cell Death & Disease, 2026, 17(1): 198.前往小宇宙评论区与主播互动