EPISODE · Aug 16, 2026 · 18 MIN
1445-Atx2在JNK信号通路激活中的保守作用
from 聊聊Sci
这篇文章揭示了Atx2蛋白在调节JNK信号通路中的关键作用。研究指出，Atx2通过直接结合并稳定hipk mRNA，增强了上游激酶的表达，进而激活细胞凋亡、迁移和组织重塑。实验证明，干扰Atx2能有效抑制果蝇体内的肿瘤生长与侵袭，而其过表达则会加剧组织损伤。这种调控机制在进化上高度保守，人类直系同源蛋白ATXN2L在海拉细胞中同样表现出诱导JNK激活的功能。该发现不仅深化了对炎症与癌症分子机理的理解，还为相关病理治疗提供了潜在的新靶点。References:Li X, Zhu X, Li W, et al. Conserved role of Atx2 in JNK pathway activation[J]. Cell Death & Disease, 2026.前往小宇宙评论区与主播互动
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1445-Atx2在JNK信号通路激活中的保守作用
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