1450-UBC9介导的CORO1C苏木化促进肺腺癌进展

这项研究揭示了UBC9介导的蛋白质修饰在驱动肺腺癌（LUAD）恶性进展中的关键机制。研究发现，UBC9酶在肺腺癌组织中异常高表达，并与患者的不良预后密切相关。通过分子实验，作者鉴定出CORO1C蛋白是UBC9的主要底物，其发生的SUMO化修饰能够显著增强其与Arp2/3复合物的结合。这种相互作用触发了癌细胞内的细胞骨架重塑，从而增强了肿瘤的增殖、迁移和侵袭能力。最终，研究表明阻断这一调节轴或使用Arp2/3抑制剂可有效抑制肿瘤生长，为治疗晚期肺腺癌提供了新靶点。References:Zhang Z, Xiao B, Jiang Y, et al. UBC9-mediated SUMOylation of CORO1C drives lung adenocarcinoma progression via Arp2/3-dependent cytoskeletal remodeling[J]. Cell Death & Disease, 2026.前往小宇宙评论区与主播互动

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1450-UBC9介导的CORO1C苏木化促进肺腺癌进展

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