1462-Hypoxia-Induced Sorafenib Resistance in HCC

This research identifies CD147-positive migrasomes as a critical driver of sorafenib resistance in hepatocellular carcinoma. The study demonstrates that hypoxic conditions trigger the release of these large extracellular vesicles, which are internalized by cancer cells through LPAR6-dependent macropinocytosis. Once absorbed, these migrasomes activate the PI3K/AKT/TWIST1 signaling pathway, promoting vasculogenic mimicry to provide alternative blood supply for tumor survival. The authors conclude that dual-targeting of the uptake process and mimicry formation could effectively restore the efficacy of sorafenib. These findings offer a novel therapeutic strategy for overcoming drug resistance in aggressive liver cancer.References:Qian L, Chen P, Wang B, et al. CD147-positive migrasome macropinocytosis promotes HCC sorafenib resistance via inducing vasculogenic mimicry triggered by PI3K/AKT/TWIST1 signaling[J]. Cell Death & Disease, 2026.前往小宇宙评论区与主播互动