1465-利用从头设计蛋白实现膜蛋白可溶化

这项研究介绍了一种名为WRAP的创新蛋白质设计方法，旨在通过人工智能驱动的深度学习工具解决膜蛋白难以溶解和研究的长期挑战。研究人员利用RFdiffusion和ProteinMPNN等计算模型，开发出能够包裹膜蛋白疏水区域的人造两亲性蛋白，使其无需除垢剂即可在水中保持稳定。通过将这些设计的WRAP与目标膜蛋白基因融合，科学家们能够直接在大肠杆菌细胞质中表达并纯化出具有生物活性的可溶性蛋白。实验证明，该技术成功应用于多种复杂的膜蛋白，包括梅毒螺旋体抗原、人类GPCR受体以及高分辨率的分枝杆菌孔蛋白结构测定。这一突破性进展为疫苗研发、药物筛选及膜蛋白的高精度结构分析提供了更加高效且低成本的新途径。References:Mihaljević L, Kim D E, Bandawane P D, et al. Membrane protein solubilization and structure determination using de novo–designed proteins[J]. Science, 2026, 393(6806): eadr3817.前往小宇宙评论区与主播互动

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1465-利用从头设计蛋白实现膜蛋白可溶化

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