1466-Single-Cell Multiomics of Neuronal Activation

This research article details a large-scale study on single-cell multiomics to understand how neuronal activation reveals the genetic foundations of neuropsychiatric disorders (NPD). By stimulating human-derived neurons and analyzing their gene expression and chromatin accessibility, researchers identified thousands of context-specific genetic variants that are invisible in resting states or postmortem brains. The results highlight that activity-dependent processes, particularly those related to cholesterol and lipid metabolism, are critical to the development of conditions like schizophrenia and autism. Furthermore, the study utilizes gene regulatory networks to map how specific transcription factors control disease-linked responses. Ultimately, this work demonstrates that cell stimulation is a powerful tool for uncovering hidden genetic effects that contribute to brain disorders.References:Liang L, Zhang S, Wang Z, et al. Single-cell multiomics of neuron activation reveals context-specific genetics of brain disorders[J]. Science, 2026, 392(6805): eadw3949.前往小宇宙评论区与主播互动