1474-社会记忆中效价更新的神经环路机制 episode artwork

EPISODE · Aug 22, 2026 · 23 MIN

1474-社会记忆中效价更新的神经环路机制

from 聊聊Sci

这项研究揭示了大脑中vCA1–BLA–NAc神经环路在更新社交记忆效价中的核心作用。研究发现,虽然海马体vCA1区域存储了稳定的个体身份信息,但其与基底侧杏仁核 (BLA) 之间的突触可塑性增强是区分“侵略者”与“非侵略者”的关键。当原本中性的个体变得具有攻击性时,vCA1的社交记忆印迹细胞会加强与BLA恐惧神经元的连接,进而激活下游伏隔核 (NAc) 中的D2受体表达神经元。这种环路机制使动物能够根据以往的社交互动,灵活地为特定个体贴上负面标签并产生选择性社交回避。通过光遗传学和化学遗传学手段,研究人员证明了这一环路对维持和检索更新后的社交情感至关重要,而非针对所有个体的普遍性恐惧。该发现为理解社交关系动态变化下的情感形成提供了神经生物学框架。References:Suto N, Wang M Y, Morikawa S, et al. Neural circuits for valence updating in social memory[J]. Science, 2026, 393(6807): eadx8231.前往小宇宙评论区与主播互动

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1474-社会记忆中效价更新的神经环路机制

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