1475-巨噬细胞修复与衰老中性粒细胞清除对器官老化的抑制作用

这项研究揭示了组织驻留巨噬细胞（TRM）在器官衰老中扮演的核心角色，其功能受损会导致衰老中性粒细胞在体内堆积。研究发现，随着年龄增长，前列腺素E2受体EP2的信号传导会抑制巨噬细胞的吞噬作用，使这些长寿的免疫细胞无法有效清除废旧的中性粒细胞。这些未能被清除的细胞会通过释放蛋白酶和产生旁分泌压力，诱发全身性炎症并导致大脑、心脏、肝脏和骨骼肌的功能衰退。通过基因敲除或使用药物抑制EP2受体，可以重新激活巨噬细胞的清除程序，显著改善老年小鼠的认知、肌力和心脏健康。该研究不仅重新定义了衰老的生物学机制——即从被动退化转向细胞清除功能的失效，还为通过药理手段逆转衰老相关疾病提供了极具潜力的治疗策略。References:Tan Y J, Conley T E, Yao F, et al. Restored clearance of senescent neutrophils by tissue-resident macrophages limits organ aging[J]. Science, 2026, 393(6808): eaea3075.前往小宇宙评论区与主播互动

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1475-巨噬细胞修复与衰老中性粒细胞清除对器官老化的抑制作用

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