EPISODE · Aug 23, 2026 · 26 MIN
1477-人类激素细胞图谱研究综述
from 聊聊Sci
这项研究构建了人类激素细胞图谱（Hormone Cell Atlas），这是一个基于1400万个单细胞转录组数据建立的开放资源，旨在从细胞层面解析激素的生成与作用。研究人员整合了来自47个健康组织的108项研究，并开发了hormone2cell分析框架，系统地描绘了162种激素及其受体在整个人体内的分布。研究发现，激素的表达具有极强的细胞类型特异性，而受体分布则非常广泛，这揭示了器官间复杂的内分泌通讯网络。此外，该图谱还揭示了免疫细胞产生激素等非传统发现，并深入探讨了脂肪细胞在肥胖背景下的内分泌演变。该成果为理解人体生理、探索内分泌疾病的分子机制以及寻找治疗靶点提供了关键的参考框架。References:Fei L, Huang-Doran I, Lawler K, et al. A Hormone Cell Atlas maps the human endocrine system at cellular resolution[J]. Science, 2026: eaeb2672.前往小宇宙评论区与主播互动
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1477-人类激素细胞图谱研究综述
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