EPISODE · Aug 24, 2026 · 15 MIN
1485-PIEZO1调控肝脏分区力学感知与再生研究
from 聊聊Sci
这项研究揭示了肝脏再生过程中一种由物理力驱动的新机制，即区带化机械感知模式。研究发现，位于肝脏中部的DPP4+区带2肝细胞充当了机械感受器的角色，能够敏锐探测由损伤引起的组织张力增加和细胞肥大。这种物理压力通过机械敏感通道PIEZO1转化为生物信号，激活IGFBP2驱动的细胞增殖程序。实验证明，缺失PIEZO1会导致肝脏修复严重受阻，而增强其活性则能显著加速组织恢复。该成果建立了组织力学与肝细胞增殖之间的直接联系，为治疗慢性肝病提供了新的干预靶点。References:Zhang Y, Sun Y, Xu G, et al. Zonated mechanosensing by PIEZO1 controls liver regeneration[J]. Science, 2026, 393(6806): eaef0825.前往小宇宙评论区与主播互动
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