EPISODE · Aug 25, 2026 · 26 MIN
1487-七鳃鳗大脑三维空间转录组图谱与脊椎动物演化研究
from 聊聊Sci
这项研究通过三维空间转录组学和单细胞核测序技术，构建了成年七鳃鳗大脑的高精度分子图谱。作为现存最古老的脊椎动物之一，七鳃鳗为揭示大脑演化蓝图提供了关键参考，研究识别出分布于14个脑区的209个细胞群。通过与小鼠、斑马鱼及多种羊膜动物的跨物种对比，科学家发现脊椎动物大脑在解剖分区上具有高度的保守性。然而，研究也揭示了显著的演化差异，特别是神经元从原始的多功能协同表达向现代的高度功能专门化转变的过程。此外，研究证实了小脑雏形在脊椎动物祖先中早已存在，这为理解复杂大脑结构的起源提供了新证据。References:Wu H, Chen D, Li J, et al. Lamprey 3D single-cell transcriptomics reveals ancestral and specialized features of the vertebrate brain[J]. Science, 2026, 392(6804): eaea2535.前往小宇宙评论区与主播互动
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1487-七鳃鳗大脑三维空间转录组图谱与脊椎动物演化研究
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